Feed-Grade Riboflavin Production
Riboflavin Production Costs Report | Issue A | Q3 2024
Report Details |
1 kta United States-based plant | Q3 2024 | 107 pages |
This report presents a cost analysis of a 1 kta (kilo metric ton per annum) United States-based plant. You can add a customized cost analysis, assuming another location (country), when ordering a premium edition of this report.
Report Abstract
This report presents the economics of feed-grade Riboflavin production via a typical direct fermentation process using glucose as carbon source in the United States. In the process examined, Riboflavin is produced by fermentation of a glucose syrup. After fermentation, the broth is pasteurized for the inactivation of the microorganisms, Riboflavin is recovered by centrifugation, subjected to a mineral acid treatment, dried and packed. The final product obtained is 96 wt% Riboflavin (feed-grade).
The report provides a comprehensive study of Riboflavin production and related Riboflavin production cost, covering three key aspects: a complete description of the Riboflavin production process examined; an in-depth analysis of the related Riboflavin plant capital cost (Capex); and an evaluation of the respective Riboflavin plant operating costs (Opex).
The Riboflavin production process description includes a block flow diagram (BFD), an overview of the industrial site installations, detailing both the process unit and the necessary infrastructure, process consumption figures and comprehensive process flow diagrams (PFD). The Riboflavin plant capital cost analysis breaks down the Capex by plant cost (i.e., ISBL, OSBL and Contingency); owner's cost; working capital; and costs incurred during industrial plant commissioning and start-up. The Riboflavin plant operating costs analysis covers operating expenses, including variable costs like raw materials and utilities, and fixed costs such as maintenance, labor, and depreciation.
Process Schematic

The process under analysis comprises two major sections: (1) Fermentation; and (2) Product Recovery and Purification.
Fermentation. Initially, the culture media used in the pre-fermentation and in the fed-batch fermentation are prepared by diluting the nutrients in water. The applied recombinant microorganism is propagated in an aerobic pre-fermentation step to obtain the proper inoculum concentration. When there is a sufficient mass of bacteria colony, the microorganism inoculum from the pre-fermentation step is fed into the fermenters. Fed-batch medium is continuously supplied to the fermenters, and the main fermentation is also carried out under aerobic process conditions. The pH control is made by addition of a solution of ammonia (NH3) and sulfuric acid, so as to keep the pH of the fermentation broth around 7. The fermentation is allowed to proceed for 48 hours, when the feeding is suspended and the fermentation is interrupted.
Product Recovery and Purification. The fermentation broth obtained in each main fermenter at the end of the fed-batch phase is fed to an agitated, jacketed tank where it is heated at about 60 °C for approximately 30 minutes for pasteurization. The pasteurized broth, rich in Riboflavin, is then fed to three decanter centrifuges operating in series for the recovery of a product with a purity of about 90 wt%. After each centrifugation step, the separated denser layer (richer in Riboflavin than in the previous step) is re-dissolved and forwarded to a subsequent centrifuge. The Riboflavin cake is treated with hot hydrochloric acid for further degradation of cells and cell constituents. The treated suspension is cooled and subsequently directed to a vacuum belt filter, where Riboflavin is separated and washed. The wet Riboflavin cake is conveyed to a rotary dryer where remaining water is removed from the Riboflavin and the dried product obtained, with a purity of 96 wt%, is finally packed.
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Production Process Information
Process Consumptions
Labor Requirements
Plant Capital Cost Summary
Operating Cost Summary
Production Costs Datasheet
Plant Capital Cost Details
Operating Cost Details
Plant Cost Breakdowns
Plant Capacity Assessment
Process Flow Diagrams
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Content Highlights
Plant Capital Cost Summary
Summary outlining the capital cost required for building the Riboflavin production plant examined
Plant Capital Cost Details
Detailing of fixed capital (ISBL, OSBL & Owner’s Cost), working capital and additional capital requirements
Plant Cost Breakdowns
Breakdown of Riboflavin process unit (ISBL) costs and infrastructure (OSBL) costs; plant cost breakdown per discipline
Operating Costs Summary
Summary presenting the operating variable costs and the total operating cost of the Riboflavin production plant studied
Operating Cost Details
Detailing of utilities costs, operating fixed costs and depreciation
Plant Capacity Assessment
Comparative analysis of capital investment and operating costs for different Riboflavin plant capacities
Production Process Information
Block Flow Diagram, descriptions of process unit (ISBL) and site infrastructure (OSBL)
Process Consumptions
Raw materials and utilities consumption figures, by-products credits, labor requirements
Process Diagrams
Process flow diagrams (PFD), equipment list and industrial site configuration
Other Riboflavin Production Cost Reports
Food-Grade Riboflavin Production
This report presents a cost analysis of food-grade Riboflavin production via a typical direct fermentation process using glucose as carbon source in the USA. In the process examined, Riboflavin is produced by fermentation of a glucose syrup. After fermentation, the broth is pasteurized for the inactivation of the microorganisms, Riboflavin is recovered by centrifugation, subjected to a mineral acid treatment, re-crystallized for further purification, dried and packed. The final product obtained is 99 wt% Riboflavin (food-grade).
Details: 2 kta United States-based plant | Q3 2024 | 107 pages | Issue B From $1,999 USD
The cost analyses presented in this report target a 2 kta (kilo metric ton per annum per annum) United States-based plant. For those interested in cost analyses considering other plant capacities and/or locations, Intratec offers a customized analysis as an optional feature.
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