Bio-Adipic Acid Production from Glucose (Fermentation Process)
Adipic Acid Production Costs Report | Issue C | Q3 2024
Report Details |
150 kta United States-based plant | Q3 2024 | 107 pages |
This report presents a cost analysis of a 150 kta (kilo metric ton per annum) United States-based plant. You can add a customized cost analysis, assuming another location (country), when ordering a premium edition of this report.
Report Abstract
This report assesses the economics of production of bio-based Adipic Acid. The process examined in this report is a fermentation process similar to BioAmber process, in which glucose is fermented to adipic acid. The process under analysis assumes a plant located in the United States.
The report provides a comprehensive study of Adipic Acid production and related Adipic Acid production cost, covering three key aspects: a complete description of the Adipic Acid production process examined; an in-depth analysis of the related Adipic Acid plant capital cost (Capex); and an evaluation of the respective Adipic Acid plant operating costs (Opex).
The Adipic Acid production process description includes a block flow diagram (BFD), an overview of the industrial site installations, detailing both the process unit and the necessary infrastructure, process consumption figures and comprehensive process flow diagrams (PFD). The Adipic Acid plant capital cost analysis breaks down the Capex by plant cost (i.e., ISBL, OSBL and Contingency); owner's cost; working capital; and costs incurred during industrial plant commissioning and start-up. The Adipic Acid plant operating costs analysis covers operating expenses, including variable costs like raw materials and utilities, and fixed costs such as maintenance, labor, and depreciation.
Process Schematic

The process under analysis comprises two major sections: (1) Fermentation; and (2) Purification.
Fermentation. The culture media used in the pre-fermentation and in the fed-batch fermentation are prepared by diluting the glucose syrup and nutrients in water. The applied recombinant microorganism is propagated in an aerobic pre-fermentation step to obtain the proper inoculum concentration. When there is a sufficient mass of bacteria colony, the microorganism inoculum from the pre-fermentation step is fed into the fermentors. Fed-batch medium is continuously supplied to the fermentors, and the main fermentation is carried out under anaerobic process conditions. The pH control is made by addition of a solution of ammonia (NH3), so as to keep the pH of the fermentation broth around 7. Due to the presence of the ammonium hydroxide, most of the Adipic Acid produced is neutralized, in such a way that the broth contains Adipic Acid mainly in its conjugate base forms.
Purification. After fermentation, biomass is separated from the broth. The clarified broth then is submitted to an ultrafiltration step, used to remove the remaining contaminants. The resulting Adipic Acid solution then passes through a salt split and two successive crystallization steps for concentration and purification. The final product obtained is 99.9 wt% Adipic Acid.
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Production Process Information
Process Consumptions
Labor Requirements
Plant Capital Cost Summary
Operating Cost Summary
Production Costs Datasheet
Plant Capital Cost Details
Operating Cost Details
Plant Cost Breakdowns
Plant Capacity Assessment
Process Flow Diagrams
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Content Highlights
Plant Capital Cost Summary
Summary outlining the capital cost required for building the Adipic Acid production plant examined
Plant Capital Cost Details
Detailing of fixed capital (ISBL, OSBL & Owner’s Cost), working capital and additional capital requirements
Plant Cost Breakdowns
Breakdown of Adipic Acid process unit (ISBL) costs and infrastructure (OSBL) costs; plant cost breakdown per discipline
Operating Costs Summary
Summary presenting the operating variable costs and the total operating cost of the Adipic Acid production plant studied
Operating Cost Details
Detailing of utilities costs, operating fixed costs and depreciation
Plant Capacity Assessment
Comparative analysis of capital investment and operating costs for different Adipic Acid plant capacities
Production Process Information
Block Flow Diagram, descriptions of process unit (ISBL) and site infrastructure (OSBL)
Process Consumptions
Raw materials and utilities consumption figures, by-products credits, labor requirements
Process Diagrams
Process flow diagrams (PFD), equipment list and industrial site configuration
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