Commodity Production Costs Report
Paracetamol Production from p-Nitrochlorobenzene
Paracetamol Operating Costs & Plant Construction Costs
This report analyses the economics of Paracetamol production from 4-nitrochlorobenzene and acetic anhydride in the United States. In the process, 4-nitrochlorobenzene reacts with sodium hydroxide producing para nitro phenol (PNP). The PNP is then subjected to reduction, producing para amino phenol (PAP). The PAP is then acetylated to produce Paracetamol.
The report provides a comprehensive study of Paracetamol production and related Paracetamol production cost, covering three key aspects: a complete description of the Paracetamol production process examined; an in-depth analysis of the related Paracetamol plant capital cost (Capex); and an evaluation of the respective Paracetamol plant operating costs (Opex).
The Paracetamol production process description includes a block flow diagram (BFD), an overview of the industrial site installations, detailing both the process unit and the necessary infrastructure, process consumption figures and comprehensive process flow diagrams (PFD). The Paracetamol plant capital cost analysis breaks down the Capex by plant cost (i.e., ISBL, OSBL and Contingency); owner's cost; working capital; and costs incurred during industrial plant commissioning and start-up. The Paracetamol plant operating costs analysis covers operating expenses, including variable costs like raw materials and utilities, and fixed costs such as maintenance, labor, and depreciation.
Key reference(s): ?
The process under analysis comprises three major sections: (1) P-nitrochlorobenzene hydrolysis; (2) P-nitrophenol reduction; and (3) P-aminophenol acetylation.
P-nitrochlorobenzene hydrolysis. Initially, p-nitrochlorobenzene (PNCB) reacts with caustic soda in an autoclave, yielding p-nitrophenol (PNP) and sodium chloride. The PNP formed is concentrated in a low-pressure vessel, eliminating water and volatile impurities. The product is further purified by acidification with sulfuric acid, crystallization and centrifugation.
P-nitrophenol reduction. The PNP and gaseous hydrogen are fed to a reactor, where the PNP is hydrogenated to p-aminophenol (PAP) in an acetic acid solvent medium, in the presence of platinum/carbon catalysts. The reaction mixture containing p-aminophenol is cooled and passed through a filter, in which catalyst is filtered from the solution.
P-aminophenol acetylation. The p-aminophenol solution is fed to a reactor along with acetic anhydride. An acetylation reaction is carried out by heating the mixture of p-aminophenol with acetic anhydride, yielding crude Paracetamol. The crude Paracetamol is mixed with water and sulfuric acid and treated with decolorizing charcoal. The product is further purified by crystallization/centrifugation steps, and subsequently dried, ground under a dry air atmosphere, packed and stored.
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Content Highlights
Plant Capital Cost Summary
Summary outlining the capital cost required for building the Paracetamol production plant examined.
Plant Capital Cost Details
Detailing of fixed capital (ISBL, OSBL & Owner’s Cost), working capital and additional capital requirements.
Plant Cost Breakdowns
Breakdown of Paracetamol process unit (ISBL) costs and infrastructure (OSBL) costs; plant cost breakdown per discipline.
Operating Costs Summary
Summary presenting the operating variable costs and the total operating cost of the Paracetamol production plant studied.
Operating Cost Details
Detailing of utilities costs, operating fixed costs and depreciation.
Plant Capacity Assessment
Comparative analysis of capital investment and operating costs for different Paracetamol plant capacities.
Production Process Information
Block Flow Diagram, descriptions of process unit (ISBL) and site infrastructure (OSBL).
Process Consumptions
Raw materials and utilities consumption figures, by-products credits, labor requirements
Process Diagrams
Process flow diagrams (PFD), equipment list and industrial site configuration
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Other Paracetamol Production Cost Reports
Paracetamol Production from Nitrobenzene
This report approaches the production of Paracetamol from nitrobenzene and acetic anhydride in the United States. In this process, nitrobenzene is contacted with hydrogen in the presence of dilute sulfuric acid, generating 4-aminophenol (PAP) and aniline by-product. The PAP is then acetylated to produce Paracetamol.
Details: 20 kta United States-based plant | Q3 2024 | 107 pages | Issue B | From $1,999 USD
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This report approaches the conversion of Paracetamol granules into tablets. The economic analysis is based on a plant located in the United States.
Details: 4.8 kta United States-based plant | Q3 2024 | 107 pages | Issue C | From $1,999 USD
Paracetamol Production from p-Nitrophenol
This report analyses the economics of Paracetamol production from p-nitrophenol (PNP) and acetic anhydride. The PNP is then subjected to reduction, producing p-aminophenol (PAP). The PAP is then acetylated to produce Paracetamol. The economic analysis is based on a plant located in the United States.
Details: 20 kta United States-based plant | Q3 2024 | 107 pages | Issue D | From $1,999 USD
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